The Fantastic Four have been shrunken to small size. Dr. Doom is after them and takes them to the Micro World. Dr. Doom briefs them on his micro genius experiments involving a king and a princess from the micro world. The four battle the giant guards but Dr. Doom catches them and imprisons them with the King and Princess. They all escape and enlarge themselves. Ben puts a stop to the Lizard Men, then the four return to their own world.