The 2021 Fastlane was the sixth and final Fastlane professional wrestling pay-per-view (PPV) and livestreaming event produced by WWE. It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. The event took place on March 21, 2021, from the WWE ThunderDome, hosted at Tropicana Field in St. Petersburg, Florida—it was WWE's final PPV presented from Tropicana Field during the COVID-19 pandemic as the ThunderDome was relocated to the Yuengling Center in Tampa, Florida due to the start of the 2021 Tampa Bay Rays season. It was the first Fastlane event held since 2019. It was also WWE's first PPV event to livestream on Peacock in the United States, and the last to be available on the standalone version of the American WWE Network before its shutdown on April 4.