Jackie Markham, a feisty trucking company manager, picks up a prescription near her home and vanishes. Markham’s friends and family are certain the 51-year-old workaholic would never abandon her responsibilities to her job or her adored children and grandchildren. A boyfriend reports that Markham made a mysterious phone call the night she vanished, warning him that a rival suitor was at her house and drunk. He claims to have raced to her house, but found her gone. The sheriff has his doubts, but then her purse is found in a ditch in a rough neighborhood not far from a serial killer’s lair, and the case takes a much darker turn.